Monday, January 18, 2016

Despair and Hope in Tolstoy’s Anna Karenina

Despair and Hope in Tolstoy’s Anna Karenina

Tolstoy’s Anna Karenina doesn’t end with the suicide of Anna. Its final section concludes the story of its other primary character, Constantin Levin. Levin’s situation is very different from Anna’s. He is married to the woman he loves, who has recently given birth to their first child, a healthy son. They live on a farm amidst the beautiful Russian countryside and he is well-liked by the peasants under his employ. Despite his obvious good-fortune, he too has feared himself close to suicide. The reason is his inability to affirm faith in God. His most diligent inquiries have left him without the certainty he craves. All he knows is that the conclusions of materialism are emotionally and morally unacceptable but that a convincing case for God’s existence and beneficence continually evades him. The insensate horror that would define a godless world, and the sustaining silence where he expects to hear God speak, leave him in a state of panicked existential despair. His happiness cannot gain purchase in the roiling cauldron of his unbelief.

But Levin experiences a revelation. He discovers, once and for all, that God is ultimately ineffable. He discovers that faith is not probity in matters of theology but rather the blissful acceptance of the utter necessity of an all-loving presence in the universe (acceptance which, in our fallen state, depends upon a kind of moral probity). After this revelation he witnesses how it fails to change his social being; he still behaves rudely and uncharitably to his servants and to his family. He does not allow that to derail his new understanding. He accepts that he is an imperfect social being and commits himself to understanding further the mystery of his own nature as a created being among other created beings. He surrenders himself to love, just as Anna could not.

Tolstoy’s moral genius lies in the way he delineates Levin’s deep and lasting, yet subtle and fundamentally private transformation by his new insight into the nature of the divine. Levin does not instantly attain saintliness—far from it. He must negotiate the challenges of the human world just as before, prey to the same vanities and resentments, but he can now do so possessed of new gifts: the knowledge of his own blessedness in the company of those around him and the freedom of a soul without fear.

Anna becomes, at the end, consumed by the belief that hatred permeates all human relationships. She comes to see the world and everything in it as irredeemably ugly. The social world she sees as a sick and malicious charade whose awful conceit infects her relations with those she loves. Her bright and blazing consciousness, her huge and hungry soul, cannot survive the littleness of the world around her. Her otherworldly charm outshines, and so conceals, a fatal fragility of spirit. The reader is left with the powerful and painful impression that Anna’s destruction was not inevitable. At the moment that she takes her life she is shocked at her own actions. She cannot understand, in those final instants, why she is doing it.

If Anna’s tragic journey marks the worst kind of moral waste, then Levin’s journey marks the opposite. From humiliation and despair (his wife at first rejects his proposal) he salvages, despite his own abundant failings, the joyous future he dreamed of. He witnesses the full horror of mortality in his brother’s agonizing demise and the bitter regrets that are poured out in this process. He witnesses also the true power of human compassion in his wife’s saintly nursing of his dying brother, and in the marvelous, delicate form of his newborn child.

Both Anna and Levin suffer and inflict cruelties, some inconsequential, others grave. Anna becomes the victim of the countless unacknowledged cruelties that constitute, as she sees it, the totality of the social world. Levin transcends such cruelties, ready, we sense, to forgive them in himself and in others. There is profound sadness in this literary masterpiece, but Tolstoy does not close the door on consolation. Having shown us two young families (Anna’s two families) torn apart by subtle deceptions, he shows us another thriving in the consciousness of their sacred bond.

The triumph of literature is to offer each of us vivid evidence of lives beyond our own, to speak to us out of the vast invisible worlds that other people carry in them. Tolstoy’s miraculous feat, in showing us Anna and Levin, is to swing two worlds into alignment, to confront the darkness that surrounds them and threatens to swallow us all, and to look beyond, to the blaze of countless galaxies, to the spangled majesty of love.

Editor’s note: The image above, titled “Portrait of an Unknown Woman,” was painted by Ivan Kramskoy in 1883.



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Friday, January 15, 2016

Garlic Soup! 100 Times More Efficient Than Antibiotics!

Garlic Soup! 100 Times More Efficient Than Antibiotics!

Traditional garlic soup can be of great help when it comes to treating flu, cold or Norovirus. It is made of basic ingredients like garlic, of course, red onion and thyme. Fortunately, people tend to use natural remedies instead of antibiotics or any other medication that is commonly prescribed to individuals dealing with cold or flu.

Wonder why? Viruses have become more dangerous and resistant to drugs. The Norovirus worries health experts, because in addition to its symptoms, it also causes vomiting. In 2012 it was known as ‘Sydney’ and it does not trigger symptoms different than others, but it sure causes vomiting, diarrhea, fever, headache and stomach cramps.

garlic-soup-100-times-more-efficient-than-antibiotics

Garlic has the power to stand still against mutation changes in viruses. It shows great success in the fight against new and mutated viruses. It is all about its allicin content. A group of researchers at the Washington University conducted a study involving this particular issue.

They found that garlic is pretty mighty. It is 100 times more powerful that the 2 most common antibiotics used in the treatment of various diseases caused by particular bacteria that is held as responsible for the occurrence of diseases transmitted by food.

Garlic soup

Eat garlic regularly, and this is the best advice you can get. Add it to your favorite meals, salad, combine it with olive oil or just spread it over a slice of bread. In this way you can stay healthy and safe from diseases. The latest research never saw the light and it was never finished, because the Big Pharma is simply not interested in natural and cheap remedies.

Recipe

  • 50 garlic cloves or 5 bulbs, peeled
  • 2 tbsp butter
  • 2 tbsp olive oil
  • 2 large onions, diced
  • 1 tbsp fresh thyme, chopped
  • 6 cups clear chicken broth
  • a bunch of fresh herbs (parsley, thyme, bay leaf) -*you can always use dried herbs instead of fresh
  • 3 cups stale bread, diced
  • 1 cup sour cream

Preparation

First, preheat your oven, and 180 degrees is just perfect. Cut off the top of each garlic bulb or just separate the cloves and spread them over a piece of aluminum foil. Drizzle over some olive oil and roast your garlic for hour and a half. When it is ready, take your garlic out of the oven and let it cool for a few minutes.

In the meanwhile, heat 2 tablespoons of olive oil and some butter in a pot. Your recipe requires medium heat. Add in your onions and cook everything for 10 minutes. Once your garlic is beautifully roasted, mash it using a fork, and add it into the pot. Next add your herbs and chicken broth.

Reduce the heat to low, add the bread and cook for additional 5 minutes, or until the bread cubes become soft. Blend your soup until smooth, and you can use either a immersion blender or your regular blender. Return the creamy mixture to the heat, and add in some sour cream. Season with salt and pepper to taste.

If you notice any initial symptoms that may indicate a particular ailment, do not hesitate to have a serving of this healing soup. It sure takes a while to prepare it, but you can always freeze whatever you are left with and this will also save you some time. The ingredients in this soup create a magical combination and this soup is sure worth trying!

Source: www.myfitmagazine.com

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Wednesday, January 13, 2016

The Divine Comedy

Healing from Pornography with The Divine Comedy

If you haven’t yet read The Divine Comedy, the Year of Mercy is the time to do it. Named by Pope Francis as one of his favorite books, this narrative poem by the fourteenth-century Italian poet Dante Alighieri is widely considered to be the most preeminent work of Italian literature, as well as one of the greatest poems ever written. The impact of this work was so monumental that by writing The Divine Comedy in the Tuscan dialect, Dante laid the foundation for a nationalized Italian language.

But what, you may ask, does this epic poem’s 100 cantos have to do with pornography? At first glance, The Divine Comedy is a fictional recounting of Dante’s journey through the afterlife—the Inferno (hell), Purgatorio (Purgatory), and Paradiso (heaven). At a deeper level, however, it is an allegory of the soul’s journey to God, which often includes recognizing, renouncing and healing from sin.

When someone starts using pornography, their gradual descent into addiction is quite similar to the opening of The Divine Comedy, when Dante awakens from slumber only to find himself lost in the woods. I don’t mean that one cannot be immediately fascinated by pornography, but that if one continues to view it regularly, those hooks of pornography, as it were, will sink deeper and deeper into a man’s heart, until what he thought he could walk away from at any point in time, he now realizes he cannot. 

The question becomes, then, what does one do to make it out of the woods, to break free from the enslavement that pornography brings? For true healing to take place, pornography users usually travel a path quite similar to Dante’s journey.

Resolve. The first action that is necessary is to recognize that you are, in fact, lost. When Dante realized he had strayed from the true path, he set his eyes upon the heights of Mount Joy and immediately began to attempt an ascent. When a man, trapped by pornography, sees what he is turning into, and how pornography has distorted his sense of self-worth, his masculine identity, his view of women and so forth, he is rightly repulsed and immediately resolves to do better, to be better. “I will never do this again,” he may say in all sincerity as he strives to be the man he was created to be.

Discouragement. Despite his best intentions to ascend Mount Joy, Dante is almost immediately blocked by three wild animals. In the same way, a man’s resolve is often threatened by the vice he has become accustomed to. He wants purity of heart, self-mastery, perhaps even sanctity, but he feels unable to attain it. And since his habit of pornography has trained him to be soft and undisciplined, he is faced with the fact that this ascent to freedom will be much harder than he first thought. Just as Dante was driven back into the dark wood by the she-wolf of incontinence, so the addicted man is driven back to the thing he perceives to bring comfort and escape. In his discouragement, he will be tempted by what Friedrich Nietzsche called ressentiment, where one demonizes a good he feels unable to attain. This hopelessness was expressed well by St. Augustine in the Confessions:

I was sighing, all bound as I was, not by external chains, but by the chain of my own will. The enemy had possession of my will, and in this way he had involved me in a chain by which he held me bound. An unlawful desire is indeed produced by a perverse will, and in obeying an unlawful desire a habit becomes established; and when a habit is not restrained it grows into a necessity.

Courage. Just as Dante may have been tempted to give up and go home, Beatrice sends Virgil—a beacon of reason—to lead him on a journey he at first felt ill-equipped to undertake. Similarly, Our Blessed Lord has given us the faculty of reason, the weapons of his grace, and his unfaltering, perfect love. With these things, “we are more than conquerors through him who loved us” (Rom 8:37). The journey back to wholeness may be daunting, but “with God all things are possible” (Matt 19:26).

Recognition of Sin. Together, Virgil and Dante descend into the Inferno, wherein Dante begins to recognize sin for what it is. While Dante doesn’t reference pornography specifically in The Divine Comedy, he does speak of “the carnal,” those who chose to commit certain sexual sins. In the second circle of hell, Dante encounters a couple being whipped around violently, as if by a great whirlwind. He calls out “O wearied souls” and the two—Paolo and Francesca—are permitted to pause to tell them the story of how they committed adultery.

The story of Paola and Francesca, forced to reenact their lustful gaze forever in Hell, can teach us several things about the reality of porn. First, just like the whirlwind in which the carnal find themselves, lust and pornography can excite, but cannot satisfy. Turning to pornography for sexual satisfaction is like a man who turns to salt water to satiate his burning thirst. It doesn’t work. Second, notice that Dante calls Paolo and Francesca “weary souls,” an apt description for the ones who have traded in reason for unbridled passion that neither satisfies nor consoles. Third, the whirlwind wherein Francesca and Paolo are forced to eternally look upon the shade of the other’s body serves as a mutual reminder of their sin. When we sin sexually with another, we are not loving the other, we are using the other. This is particularly evident in pornography where the user treats the other, not as a person with intrinsic dignity, or even with a mind of her own, but as a sex object.

Renunciation of Sin. To his relief (and many generations of readers), Dante leaves Hell and moves into Purgatory. If Hell was where Dante recognized sin, Purgatory is where he learns to renounce it. Within Canto XIX, Dante encounters a mysterious woman from whom we can learn that the degree to which we recognize the reality behind the fantasy of pornography will greatly affect our ability to renounce it.

When Dante first lays eyes on this woman—who represents the abandonment of reason to physical appetite—he writes,

There came to me in a dream a stuttering crone,
squint-eyed, clubfooted, both her hands deformed,
and her complexion like a whitewashed stone.

In my experience, this is usually the reaction people have when they first encounter hard-core pornography. It is jarring, unbeautiful, and unwelcome.

However, what happens next to Dante is most certainly analogous to the way in which pornography that once seemed disturbing can become increasingly attractive to us. Dante writes,

I stared at her; and just as the new sun
breathes life to night-chilled limbs, just so my look
began to free her tongue, and one by one

drew straight all her deformities, and warmed
her dead face, till it bloomed as love would wish it
for its delight. When she thus transformed,

her tongue thus loosened, she began to sing
in such a voice that only with great pain
could I have turned from her soliciting.

While hard-core pornography may at first repulse, if we stare upon it long enough, as Dante stared upon the woman, we begin not only to like it, but crave it. We become intoxicated. Soon, that which should be offensive seems wholesome.

When a man is tempted to look at porn or is committing the very act of looking at it, his conscience—if he hasn’t almost killed it—is calling out to him, urging him back to sanity. If, by God’s grace, he listens to it, he will in an instant see the vileness of the act he is committing, rise there and then, and flee.

In this scene, Dante experiences a similar prick of conscience, caused by a heavenly woman who appears and summons Virgil (who, you will remember, represents reason) to strip the mysterious woman of her attractive façade.

He seized the witch, and with one rip laid bare
all of her front, her loins and her foul belly:
I woke sick with the stench that rose from there.

I turned then and my Virgil said to me I have called at least three times now. Rise and come.

It is when we finally see past the false promises of pornography and cling to the assistance the Lord and reason provide, that we are able to move forward on our spiritual journey.

The Path of Grace. Of course, the journey to freedom from pornography—or any sin—extends well beyond one moment of renunciation. Throughout Purgatorio, we watch as souls experience the purification necessary to one day enter Paradise.

It is tempting, when attempting to recover from an addiction to pornography, to think that once sin is renounced, we are healed—we are free. Consider the moment when, in Purgatory (Canto XXV), Dante follows Virgil along a “narrow path along a ledge” where below the lustful are being purified by fire. Virgil repeatedly says “walk only where you see me walk,” reminding Dante and us that it is all too easy to slip back into sinful behavior—we must continue to be vigilant, recognizing that casting off vice is a process.

It is important to note that, while Dante is able to witness the joys of Heaven while he is still alive for the purposes of this poem, this is not entirely the case for us. Certainly, a porn addict can recover and live a life full of authentic, self-giving love. Yet, disordered appetites and the temptation to lust will never completely disappear, because we are fallen human beings. We must continue to strive, every day, to renounce sin, even after being “sober” from pornography use for quite some time.

Dante does give us hope, though, of a place and time when these misguided appetites will be eradicated completely. At the end of The Divine Comedy, full of awe at the wonders of heaven, Dante exclaims,

Here my powers failed my high imagination:
But by now my desire and will were turned,
Like a balanced wheel rotated evenly,

By the Love that moves the sun and the other stars. (Paradiso, XXIII, 142-145.)

Editor’s note: The image above titled “The Ghosts of Paolo and Francesca Appear to Dante and Virgil” was painted by Ary Scheffer in 1855.



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Tuesday, January 12, 2016

DVD Organization

DVD Organization: How to Fit a Lot of Movies Into a Small Organized Space

Tired of your DVDs taking up so much space on the shelf? Or not being able to find the movie you want? You won't want to miss this easy efficient method for DVD organization where you can fit all your movies into a small organized space!

 

 

  

  

BEFORE - Tired of your DVDs taking up so much space on the shelf? Or not being able to find the movie you want? You won't want to miss this easy efficient method for DVD organization where you can fit all your movies into a small organized space!

 organizing with small spaces 


 

Tired of your DVDs taking up so much space on the shelf? Or not being able to find the movie you want? You won't want to miss this easy efficient method for DVD organization where you can fit all your movies into a small organized space!

Whether you have a couple dozen movies or a couple hundred, this idea for DVD organization will keep your movies nicely sorted into a small space.

 

Tired of your DVDs taking up so much space on the shelf? Or not being able to find the movie you want? You won't want to miss this easy efficient method for DVD organization where you can fit all your movies into a small organized space!

Two things to note before we get started:

 

 

 

   

Toss it.

  can  

Tired of your DVDs taking up so much space on the shelf? Or not being able to find the movie you want? You won't want to miss this easy efficient method for DVD organization where you can fit all your movies into a small organized space!

  •  Rubbermaid Bento Medium Storage Boxes  Amazon
  • movie sleeves  Atlantic movie sleeves new version 
  •  

   

Tired of your DVDs taking up so much space on the shelf? Or not being able to find the movie you want? You won't want to miss this easy efficient method for DVD organization where you can fit all your movies into a small organized space!

    

 

Tired of your DVDs taking up so much space on the shelf? Or not being able to find the movie you want? You won't want to miss this easy efficient method for DVD organization where you can fit all your movies into a small organized space!

  

Tired of your DVDs taking up so much space on the shelf? Or not being able to find the movie you want? You won't want to miss this easy efficient method for DVD organization where you can fit all your movies into a small organized space!

Tired of your DVDs taking up so much space on the shelf? Or not being able to find the movie you want? You won't want to miss this easy efficient method for DVD organization where you can fit all your movies into a small organized space!

   

Tired of your DVDs taking up so much space on the shelf? Or not being able to find the movie you want? You won't want to miss this easy efficient method for DVD organization where you can fit all your movies into a small organized space!

  perfect    

Tired of your DVDs taking up so much space on the shelf? Or not being able to find the movie you want? You won't want to miss this easy efficient method for DVD organization where you can fit all your movies into a small organized space!

  

Tired of your DVDs taking up so much space on the shelf? Or not being able to find the movie you want? You won't want to miss this easy efficient method for DVD organization where you can fit all your movies into a small organized space!

  Friends  

Tired of your DVDs taking up so much space on the shelf? Or not being able to find the movie you want? You won't want to miss this easy efficient method for DVD organization where you can fit all your movies into a small organized space!

  

Tired of your DVDs taking up so much space on the shelf? Or not being able to find the movie you want? You won't want to miss this easy efficient method for DVD organization where you can fit all your movies into a small organized space!

 

Tired of your DVDs taking up so much space on the shelf? Or not being able to find the movie you want? You won't want to miss this easy efficient method for DVD organization where you can fit all your movies into a small organized space!



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Monday, January 11, 2016

Columbo Technique

Columbo Technique

Techniques > Questioning > The Columbo Technique

Get them talking | Slip in the real question | One last thing | See also

Lieutenant Columbo, as played by Peter Falk in the 1970s television series 'Columbo', uses a questioning technique that has been successfully adopted by more than just policemen.

Columbo uses two steps to his method: (a) Get them talking, and then (b) Slip in the real question.

Get them talking

Columbo starts with casual open questions, just to put the other person at ease and get them freely talking. His shabby dress and ambling gait signals that he is harmless. When he talks, his confused demeanor further indicates a level of apparent incompetence, confirming the first impressions of harmlessness.

He is friendly and a welcome respite from the more threatening other policemen who are often around (making this a subtle use of the good-cop, bad-cop 'Hurt and Rescue' routine). His inconsequential chatter loosens their tongues and before long they are happily engaged in distracting conversation.

Slip in the real question

When the other person is sufficiently relaxed and Columbo has achieved good bonding, he slips in a question about what he really wants to know.

One of the tricks he uses is to phrase the question indirectly. If he wants to know whether a person drives a red car, he picks up something red and talks about a car he used to have that was the same shade of red. The conversation might go something like this:

"This is a nice clock. You know, I used to have a car exactly the same color as this. Chevvy, it was."

"Hey, I've got a red Chevvy!"

"Have you? Well, you know mine was a pretty good one."

"Well mine's a '56. Special convertible!"

"There aren't too many of those around."

"Yeah, I got it from a guy down on 52nd Street."

And now Columbo has found a very useful clue without the other person every realizing that they have given the game away.

One last thing

The other variant that Columbo used, again when the other person's defenses  were down, would be to add one last question just as he is leaving.

"Oh, ah, is that your cousin's car outside?"

The person being questioned has already reached closure on the session and is looking forward to the complete closure of being left alone. Columbo's question thus catches them off their guard and they answer him without thinking, just to get him out of the way.

And one last thing: 'One last thing' statements (not questions) can also be used to leave the person in a state of tension as Columbo drops a big gotcha just before he leaves (and without letting the other person achieve closure by responding).

"...oh yes, I forgot -- your cousin said he lent you the car last week."

See also

Closure principleConfusion principleHurt and Rescue principle



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10 Ways To Resist The Devil

10 Ways To Resist The Devil

It is one of the Bible’s many sweet and powerful promises: “Resist the devil and he will flee from you” (James 4:7). The question is, though, how do we do this? In very practical ways, how do we resist the devil? Thomas Brooks offers a list of ten ways the Christian can resist Satan’s temptations.

1. Be Ruled by the Word. Make the Word of God your rule and authority and live in obedience to all it says. It will keep you walking straight and guard you from all manner of temptation. “When men throw off the Word, then God throws off them, and then Satan takes them by the hand, and leads them into snares at his pleasure.”

2. Beware of Grieving the Holy Spirit. It is the Holy Spirit that gives the Christian the ability to discern Satan’s temptations and to see his hand in and behind life’s circumstances. If you grieve the Spirit, you drive off the one whose ministry involves guarding you against Satan’s attacks.

3. Labor for Wisdom. There is a great difference between knowledge and wisdom, between accumulating facts and applying Scripture to those facts so they become wisdom. It is not the Christian with the most knowledge, but the Christian with the most wisdom, who is equipped to battle Satan’s temptations.

4. Resist the First Stirring of Temptation. It is safe to resist temptation and dangerous to dabble in it. “He that will play with Satan’s bait, will quickly be taken with Satan’s hook.” God promises that we can resist temptation, not that we can resist sin once we have begun to dabble in that temptation.

5. Labor to Be Filled With the Spirit. The Spirit is a Spirit of light and power. The Spirit’s light shines bright against the darkness of sin and his power is sufficient to overcome all evil and temptation. When it comes to fighting Satan’s temptations, it is better to have a heart filled with the Spirit than a head filled with facts.

6. Keep Humble. A humble heart would rather lie in the dust than rise to prominence by sinful means; it would prefer to lose everything than to sin and be left with a guilty conscience. The humble person is neither drawn in by what Satan offers, nor terrified by his threats.

7. Be Constantly on Guard. A secure soul is a soul in a position to be led astray and ensnared. “That soul that will not watch against temptations, will certainly fall before the power of temptations.” Satan strengthens his assaults when the soul grows drowsy and careless. So be constantly on guard. “Watchfulness is nothing else but the soul running up and down, to and fro, busy everywhere; it is the heart busied and employed with diligent observation of what comes from within us, and of what comes from without us and into us.”

8. Continue Communing With God. It is as you join in communion with God that he gives you strength to resist Satan’s attacks. “A soul high in communion with God may be tempted, but will not easily be conquered. Such a soul will fight it out to the death.” Take full advantage of God’s means of grace.

9. Do Not Engage Satan In Your Own Strength. You need to draw the power, and even the desire, to resist sin from Jesus Christ and you need to do this every day. “Certainly that soul that engages against any old or new temptation without new strength, new influences from on high, will fall before the power of new temptation.” Commune with God, be on guard, be humble—do all of these things! But do not rely on them in the battle; instead, rely on Christ.

10. Pray Constantly. “Prayer is a shelter to the soul, a sacrifice to God and a scourge to the devil.” So pray and pray constantly. Tell God of your own inability to detect and respond to temptation; tell him that you are utterly dependent upon his grace; tell God that Christ’s blood has been applied to you; tell God that you are his child; ask God to deliver you from temptation for the glory of his name.

Thanks

Thanks for reading Precious Remedies Against Satan’s Devices with me. Or if you haven’t read it, thanks for indulging me with this series of articles inspired by it!

Your Turn

The purpose of this series is to read the classics together. Do feel free to leave a comment below or to leave a link to your own blog if you have chosen to discuss this book there.



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Saturday, January 9, 2016

Turmeric's 'Smart Kill' Properties Put Chemo & Radiation To Shame

Turmeric's 'Smart Kill' Properties Put Chemo & Radiation To Shame

Turmeric's 'Smart Kill' Properties Put Chemo & Radiation To Shame

The ancient Indian spice turmeric strikes again! A new study finds turmeric extract selectively and safely killing cancer stem cells in a way that chemo and radiation can not.

A groundbreaking new study published in the journal Anticancer Research reveals that one of the world's most extensively researched and promising natural compounds for cancer treatment: the primary polyphenol in the ancient spice turmeric known as curcumin, has the ability to selectively target cancer stem cells, which are at the root of cancer malignancy, while having little to no toxicity on normal stem cells, which are essential for tissue regeneration and longevity.

Titled, "Curcumin and Cancer Stem Cells: Curcumin Has Asymmetrical Effects on Cancer and Normal Stem Cells," the study describes the wide range of molecular mechanisms presently identified by which curcumin attacks cancer stem cells (CSCs), which are the minority subpopulation of self-renewing cells within a tumor colony, and which alone are capable of producing all the other cells within a tumor, making them the most lethal, tumoriogenic of all cells within most if not all cancers.  Because CSCs are resistant to chemotherapy, radiation, and may even be provoked towards increased invasiveness through surgical intervention, they are widely believed to be responsible for tumor recurrence and the failure of conventional treatment.

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The study identified the following 8 molecular mechanisms by which curcumin targets and kills cancer stem cells:

  • Down-regulation of interleukin-6 (IL-6): IL-6 is classified as a cytokine (a potent biomolecule released by the immune system) and modulates both immunity and inflammation. It's over expression has been linked to the progression from inflammation to cancer. Curcumin inhibits IL-6 release, which in turn prevents CSC stimulation.
  • Down-regulation of interleukin-8 (IL-8): IL-8, another cytokine, is released after tumor cell death, subsequently stimulating CSCs to regrow the tumor and resist chemotherapy. Curcumin both inhibits IL-8 production directly and indirectly.
  • Down-regulation of interleukin-1 (IL-1): IL-1, a family of cytokines, are involved in response to injury and infection, with IL-1 β playing a key role in cancer cell growth and the stimulation of CSCs. Curcumin inhibits IL-1 both directly and indirectly.  
  • Decrease CXCR1 and CXCR2 binding: CXCR1 and CXCR2 are proteins expressed on cells, including CSCs, which respond to the aforementioned cytokines in a deleterious manner. Curcumin has been found to not only block cytokine release, but their binding to these two cellular targets.
  • Modulation of the Wnt signaling pathway: The Wnt signaling pathway regulates a wide range of processes during embryonic development, but are also dsyregulated in cancer. Curcumin has been found to have a corrective action on Wnt signaling.
  • Modulation of the Notch Pathway: The Notch signaling pathway, also involved in embryogenesis, plays a key role in regulating cell differentiation, proliferation and programmed cell death (apoptosis), as well as the functioning of normal stem cells. Aberrant Notch signaling has been implicated in a wide range of cancers. Curcumin has been found to suppress tumor cells along the Notch pathway.
  • Modulation of the Hedgehog Pathways: Another pathway involved in embryogenesis, the Hedgehog pathway also regulates normal stem cell activity. Abnormal functioning of this pathway is implicated in a wide range of cancers and in the stimulation of CSCs and associated increases in tumor recurrence after conventional treatment. Curcumin has been found to inhibit the Hedgehog pathway through a number of different mechanisms.
  • Modulation of the FAK/AKT/FOXo3A Pathway: This pathway plays a key role in regulating normal stem cells, with aberrant signaling stimulating CSCs, resulting once again in tumor recurrence and resistance to chemotherapy. Curcumin has been found
  • in multiple studies to destroy CSCs through inhibiting this pathway.

As you can see through these eight examples above, curcumin exhibits a rather profound level of complexity, modulating numerous molecular pathways simultaneously. Conventional cytotoxic chemotherapy is incapable of such delicate and "intelligent" behavior, as it preferentially targets fast-replicating cells by damaging their DNA in the vulnerable mitosis stage of cell division, regardless of whether they are benign, healthy or cancerous cells.  Curcumin's selective cytotoxicity, on the other hand, targets the most dangerous cells – the cancer stem cells – which leaving unharmed the normal cells, as we will now learn more about below.

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